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Ðº6‡®e¤Å×¯‡´¾îj¹± ,û.! \“v	
Ò
(gî/™;�u3ÏäH¤„i!z!A" GÚú=^6	å	ª2¿Rx. c~Œãÿ ¸ ¨!‰" uØàyðV€	x
ë
8¨Â�’ì!Q‚»ÄÎ‹íO B!X!©#   Ý™œ3$	k	‡Êš¨ò!5£{bnš!,æx¥¸!K#B V \ ¾ w–GÍç÷ J»Í	\Í~?§È
	ŽšÂ5cßùöP÷£-iŽJÞSÏçøGg½(Uq¶ÄQ]�ù}Oú¬ ³ !,"e#Ö# M º ³¶²³‘6Ìä,³À0£©8 !°"ü" ; Xóªli‡D­¹ÂÈŸ"-  ² å µõ*AªÊaŒ¢±ù#ï
x/›õS Òfßè0D±âæ….  Ç × m!å!-#z#á#  ¸ ’I0Ò=ñÕ·¡Ð% M I#§# ÊÕLè&Œ�JXõ5¨¸Aa\bÄÒþE•!í!6"º"ù"# >½(L/]pšùê}—U é!"N"¼"®# )ÌMj‚BNTX½ëfÉÕ›Úk"#Ÿ# Þ€ž+:¾Jƒ£ýë=b™![#  ‰ ’b´Ž&‚L¦Hdãöod ×!2"#Ä#0 ) b ¦¦=·òSÑ5b¥¯<v¶	)
X
®ñÊI~ž®8ž¼ì^˜×Sh+6¯0 Æ!ï!""<"g"( D bŒ"èe�—	ß	ë	þ	
Q
”
Rø|w‹�ôýÛ”ÞùåÕe¿}G’R!Ã"#  Fð2Ó3QúÎ(	9	…	Z€³éž Wøª[‡!¼!8"ƒ"à"W# 8 3…Á:×ßGeÓ‡lj®}¨§ñý¬¹a à!É# 6¹�¥Å(,7‚!^Ô‘O‰Ý_k¼Ôßñ�!%" [þë’5	ä	Ñ
d®t³Î½íãÿú!h!% ½ v•FÌßÿ²ÌÜ[Ì}Çj	Þø7§õñ5fmPºÃùw7 « !û" WÉô)Ô‹¡/ø%ŽôwR§†·Ce¬Ç5"# (L¼9A'‚¢�™êKšaj–˜!­# 7 C ‹ÒdRÐÞu„	µ	P
÷üÚ“­­÷|»ÖÅ!ß!Â"ß" uVÈ(ÓýŠ.ZËê÷‘6cs¦â¶dˆj»ÆÞ  'ŠÒ8Ýt5ª«¬Œ c{‡Õghi¹º^_`—!Ä!Ý"Þ"  .ò  qGACNNNNNNGTC,CCAGGCCTGG,GATCCGGATC,CCWGGTACCWGG,CCANNNNNTGG,CCAGGNNNTGG,CCANNNCCTGG,CCAGGNCCTGG,GCACNNNAACGTTNNNGTGC,CACNNNGTG,CCNNNNNNNGG,AACNAACRYGTGCGTGC,GCACGCACRYGTTNGTT,GCACNAACRYGTTNGTGC,AACGCACRYGTGCGTT,GACNNNNNGTC,GAANNNNNNNTTGG,CCAANNNNNNNTTC,CACNNNNGTG,AACACNNNNGTGC,GCACNNNNGTGTT,GCANNNNNNTGC,GAACNNNNNNTCC,GGANNNNNNGTTC,CAGNNNCTG,CCAGGNNCTG,CAGNNCCTGG,CCWGGGCCC,GGGCCCWGG,CCWGGGCCCWGG,AACNNNNNNGTGCACNNNNNNGTT,GACNNNGTC,GAANNNNTTC,CCWGGTACC,GGTACCWGG,CCWGGWCCWGG,ACNNNNGTAYC,GRTACNNNNGT,CCWGGYRCCWGG,GAAGNNNNNNTAC,GTANNNNNNCTTC,AACGGCNNNGTGC,GCACNNNGCCGTT,GCACGGCNNNGTT,AACNNNGCCGTGC,CGANNNNNNTGC,GCANNNNNNTCG,CGATCNNNNTGC,GCANNNNGATCG,TGANNNNNNTCA,TGATCNNNNTCA,TGANNNNGATCA,TGATCNNGATCA,AACCTGCNNGTGC,GCACNNGCAGGTT,GCACCTGCNNGTT,AACNNGCAGGTGC,GCCNNNNNGGC,AACNNNNNNGTGCMC,GKGCACNNNNNNGTT,CCWGGNCCWGG,AACTGGGNNGTGC,GCACNNCCCAGTT,GCACTGGGNNGTT,AACNNCCCAGTGC,GACNNNNGTC,GAGNNNNNCTC,CCWGGTCTC,GAGACCWGG,GATNNNNATC,GATCNNNATC,GATNNNGATC,GATCNNGATC,CCWGGCGCCWGG,ACNNNNNCTCC,GGAGNNNNNGT,AACNNNNNNGTGCAG,CTGCACNNNNNNGTT,GATCATGATC,CCWGGNNCCWGG,AACTGGNNNGTGC,GCACNNNCCAGTT,GCACTGGNNNGTT,AACNNNCCAGTGC,AACNAACCGGTGCGTGC,GCACGCACCGGTTNGTT,GCACNAACCGGTTNGTGC,AACGCACCGGTGCGTT,GCANNNNNTGC,GCACNNNNNNGTTCGAACNNNNNNGTGC,CCTNNNNNAGG,GCNNNNNNNGC,CCANNNNNNTGG,CCAGGNNCCTGG,CCTGGCCAGG,CAANNNNNGTGG,CCACNNNNNTTG,TTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAA,GCACNNNNNNGTTTAAACNNNNNNGTGC,CCAGGNCCY,RGGNCCTGG,CCWGGGNCCTGG,CCAGGNCCCWGG,AAGNNNNNCTT,GAYNNNNNVTC,GABNNNNNRTC,GAYNNNNNRTC,GATCNNNNVTC,GABNNNNGATC,GAYNNNNGATC,GATCNNNNRTC,GATCNNNGATC,GTYAACNNNNNNGTGC,GCACNNNNNNGTTRAC,GCACNNNNNNGTTAACNNNNNNGTGC,GATCNGATC,TAACTATAACGGTCCTAAGGTAGCGA,TCGCTACCTTAGGACCGTTATAGTTA,CTCTCTTAAGGTAGC,GCTACCTTAAGAGAG,TAGGGATAACAGGGTAAT,ATTACCCTGTTATCCCTA,GTTAACNNNNNNGTGC,GCACNNNNNNGTTAAC,AACNAACGCGTGCGTGC,GCACGCACGCGTTNGTT,GCACNAACGCGTTNGTGC,AACGCACGCGTGCGTT,TCCAACNNNNNNGTGC,GCACNNNNNNGTTGGA,CAYNNNNRTG,AACAYNNNNGTGC,GCACNNNNRTGTT,GTTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAAC,CCWGGCGCC,GGCGCCWGG,CCWGGNNCC,GGNNCCWGG,GATCGCGATC,AACNAACATGTGCGTGC,GCACGCACATGTTNGTT,GCACNAACATGTTNGTGC,AACGCACATGTGCGTT,TGGCAAACAGCTATTATGGGTATTATGGGT,ACCCATAATACCCATAATAGCTGTTTGCCA,ATCTATGTCGGGTGCGGAGAAAGAGGTAATGAAATGG,CCATTTCATTACCTCTTTCTCCGCACCCGACATAGAT,AACNNGCACGTGCNNGTT,GAACNNNNNCTC,GAGNNNNNGTTC,CCAGGWCCY,RGGWCCTGG,CCWGGGWCCTGG,CCAGGWCCCWGG,CCAGGWCCTGG,TTATAACNNNNNNGTGC,GCACNNNNNNGTTATAA,GCACNNNNNNGTTATAACNNNNNNGTGC,GAACNNNNNNTAC,GTANNNNNNGTTC,GGCCNNNNNGGCC,AACNNACTAGTGC,GCACTAGTNNGTT,AACTAGTNNGTGC,GCACNNACTAGTT,AACNAACTAGTGCGTGC,GCACGCACTAGTTNGTT,GCACNAACTAGTTNGTGC,AACGCACTAGTGCGTT,AACNNNAACGTGCNNGTGC,GCACNNGCACGTTNNNGTT,GCACCCANNNGTT,AACNNNTGGGTGC,TTAACNNNNNNGTGC,GCACNNNNNNGTTAA,CACNNNNNNTCC,GGANNNNNNGTG,CACNNNNGATCC,GGATCNNNNGTG,GATCTAGATC,CCANNNNNNNNNTGG,CCAGGCCT,AGGCCTGG,CCTCGAGG,GATCCGGA,TCCGGATC,GGCGCGCC,GCGATCGC,CCWGGWCC,GGWCCWGG,GATCGATC,GATCATGA,TCATGATC,GCGGCCGC,CCTGGCCR,YGGCCAGG,CCWGGNCC,GGNCCWGG,GGCCGGCC,RTGCGCAY,GATCNNGA,TCNNGATC,CGCGCGCG,CCTGGCCA,TGGCCAGG,CGCCGGCG,GTTTAAAC,GATCGCGA,TCGCGATC,TTAATTAA,VCTCGAGB,CCTGCAGG,CRCCGGYG,CGTCGACG,ATTTAAAT,GCCCGGGC,GATCTAGA,TCTAGATC,CACCTGC,GCAGGTG,CCTNAGG,GATCGAT,ATCGATC,CCTCAGC,GCTGAGG,GCTNAGC,CCTNAGC,GCTNAGG,GCTCTTC,GAAGAGC,GGTNACC,CGGWCCG,ACCWGGT,RGGNCCY,CCTGGAG,CTCCAGG,GGTGATC,GATCACC,GATCNGA,TCNGATC,GGGWCCC,GAAGATC,GATCTTC,CCCWGGG,TCCNGGA,TCCWGGA,RGGWCCY,TTATAA,AGGCCT,GACGTC,GTMKAC,TCCGGA,TGCGCA,ACCTGC,GCAGGT,GGTACC,AGTACT,GGYRCC,CCGCTC,GAGCGG,AACGTT,YGGCCR,RAATTY,CTGAAG,CTTCAG,CACGTG,GRCGYC,AGCGCT,CTTAAG,ACRYGT,ACCGGT,ACTAGT,CACGTC,GACGTG,GWGCWC,GTGCAC,CYCGRG,GGGCCC,ATTAAT,CCTAGG,TTCGAA,GCTAGC,GKGCMC,TGGCCA,GGATCC,GRGCYC,ATCGAT,CACGAG,CTCGTG,GGCGCC,GAAGAC,GTCTTC,GCATGC,GTATCC,GGATAC,TGATCA,ACTGGG,CCCAGT,CTRYAG,RGCGCY,AGATCT,GGNNCC,CTGGAG,CTCCAG,CTTGAG,CTCAAG,CGATCG,GGTCTC,GAGACC,YACGTR,CCNNGG,GAATGC,GCATTC,WCCGGW,GCAATG,CATTGC,RCCGGY,GCGCGC,GAGGAG,CTCCTC,CGGCCG,CCCAGC,GCTGGG,GTGCAG,CTGCAC,CGRYCG,CGTACG,CGTCTC,GAGACG,CCATGG,TCGCGA,GDGCHC,TGTACA,TCATGA,ACATGT,GTATAC,CCWWGG,CTCTTC,GAAGAG,GCNNGC,CCRYGG,GTTAAC,RCATGY,TACGTA,RGATCY,GCGATG,CATCGC,GCAGTG,CACTGC,CCCGGG,CCGCGG,TTTAAA,GGCGGA,TCCGCC,GAGCTC,GATATC,CTGRAG,CTYCAG,CAGCAG,CTGCTG,GAATTC,ATGCAT,CATATG,GTYRAC,AAGCTT,GTNNAC,TCNNGA,CAATTG,ACGCGT,TCCRAC,GTYGGA,GCCGGC,CMGCKG,GCCGAG,CTCGGC,CTCGAG,CTGCAG,CAGCTG,GTCGAC,CTYRAG,AATATT,GATCGA,TCGATC,GACCGA,CACCCA,TCGGTC,TGGGTG,WGTACW,TARCCA,TGGYTA,TCTAGA,GGATC,GATCC,CCWGG,GTCTC,GAGAC,GCWGC,GGNCC,CCSGG,GGTGA,TCACC,GGWCC,GCAGC,GCTGC,CCATC,GATGG,ACGGC,GCCGT,GCNGC,CCNGG,GCATC,GATGC,ACTGG,CCAGT,GGATG,CATCC,CTCAG,CTGAG,GGGAC,GTCCC,ACNGT,CTNAG,CAGTG,CACTG,GACGC,GCGTC,CCCGC,GCGGG,GANTC,CGWCG,TCNGA,CCTTC,GAAGG,GTNAC,GAAGA,TCTTC,GAGTC,GACTC,GTSAC,GAWTC,GCSGC,CASTG,ATGAA,TTCAT,ACGGA,TCCGT,CGCG,CCGC,GCGG,GTAC,AGCT,GCGC,CTAG,GATC,GGCC,CCGG,CATG,RGCY,YATR,ACGT,TGCA,AATT,CCTC,GAGG,TTAA,ASST,TCGA                                                                                                                                                                                                                                                                                                                                                                                                         	                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
                                                                                                                                      
                                                                                                                 
                                      	                                                          
                  	                        
         	                        	                                     	         
                                              %         !   k   ~         f         7   |                                                                                                                                                                                        	                                                                                                                                                                                                                                                                                                                    
                                                    
                                         
              	                    
      	        
   	        	             	   
                %   ! k ~   f   7 |   �•  �£  �¿  �ó  ”Ç  š   ÷�Î	××uŠ‹¦·/(Î	Ú×}+=ãú`l“!¬Í)P-kØ¶Ømë#vJNœ#ë’zt˜(mtU±sÜ
"5 YªuÕãuÕãQ0ˆ/U±s¯
%.GÜA•ØJ† 
"Qýžc	î›á` 	l¿Ë“!Ý!á` 	Æl¿Ë“!á` 	l¿Ë“!¡ )¤P~ƒ�+ý�"/#v6Î $ á"W 9kQ é¶N ‹ÎW‹Ñ ¼D”rÏ*+yÞ÷
æº#¥ J þ u®®ÞŽ9ø<r
lËt" ]NÞv#ÈšNðd!´ê Öpy"î#‚9{›#z#�	E
–
ÿ~Õä<Á'&–sá—·v‘”ž°
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promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="CYC1 terminator" type="terminator" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6277-6524" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;S. cerevisiae CYC1&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;transcription terminator for &lt;i&gt;CYC1&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="3xFLAG" directionality="1" translationMW="2730.72" type="CDS" allowSegmentOverlaps="0" cleavageArrows="6212" consecutiveTranslationNumbering="1" maxRunOn="6215" maxFusedRunOn="6215" detectionMode="exactProteinMatch"><Segment range="6147-6212" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;three tandem FLAGÂ® epitope tags, followed by an enterokinase cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="DYKDHDGDYKDHDIDYKDDDDK"/></Q></Feature></Features>
  
ò<?xml version="1.0"?><Primers nextValidID="5"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/><Primer recentID="0" name="Amp-R" sequence="ATAATACCGCGCCACATAGC" description="Ampicillin resistance gene, reverse primer"><BindingSite location="9150-9169" boundStrand="0" annealedBases="ATAATACCGCGCCACATAGC" meltingTemperature="58"><Component hybridizedRange="9150-9169" bases="ATAATACCGCGCCACATAGC"/></BindingSite><BindingSite simplified="1" location="9150-9169" boundStrand="0" annealedBases="ATAATACCGCGCCACATAGC" meltingTemperature="58"><Component hybridizedRange="9150-9169" bases="ATAATACCGCGCCACATAGC"/></BindingSite></Primer><Primer recentID="1" name="CYC1" sequence="GCGTGAATGTAAGCGTGAC" description="CYC1 transcription termination signal, reverse primer"><BindingSite location="6292-6310" boundStrand="1" annealedBases="GCGTGAATGTAAGCGTGAC" meltingTemperature="56"><Component hybridizedRange="6292-6310" bases="GCGTGAATGTAAGCGTGAC"/></BindingSite><BindingSite simplified="1" location="6292-6310" boundStrand="1" annealedBases="GCGTGAATGTAAGCGTGAC" meltingTemperature="56"><Component hybridizedRange="6292-6310" bases="GCGTGAATGTAAGCGTGAC"/></BindingSite></Primer><Primer recentID="2" name="L4440" sequence="AGCGAGTCAGTGAGCGAG" description="L4440 vector, forward primer"><BindingSite location="7597-7614" boundStrand="1" annealedBases="AGCGAGTCAGTGAGCGAG" meltingTemperature="58"><Component hybridizedRange="7597-7614" bases="AGCGAGTCAGTGAGCGAG"/></BindingSite><BindingSite simplified="1" location="7597-7614" boundStrand="1" annealedBases="AGCGAGTCAGTGAGCGAG" meltingTemperature="58"><Component hybridizedRange="7597-7614" bases="AGCGAGTCAGTGAGCGAG"/></BindingSite></Primer><Primer recentID="3" name="pBR322ori-F" sequence="GGGAAACGCCTGGTATCTTT" description="pBR322 origin, forward primer"><BindingSite location="7848-7867" boundStrand="1" annealedBases="GGGAAACGCCTGGTATCTTT" meltingTemperature="56"><Component hybridizedRange="7848-7867" bases="GGGAAACGCCTGGTATCTTT"/></BindingSite><BindingSite simplified="1" location="7848-7867" boundStrand="1" annealedBases="GGGAAACGCCTGGTATCTTT" meltingTemperature="56"><Component hybridizedRange="7848-7867" bases="GGGAAACGCCTGGTATCTTT"/></BindingSite></Primer><Primer recentID="4" name="pBRforEco" sequence="AATAGGCGTATCACGAGGC" description="pBR322 vectors, upsteam of EcoRI site, forward primer"><BindingSite location="355-373" boundStrand="0" annealedBases="AATAGGCGTATCACGAGGC" meltingTemperature="57"><Component hybridizedRange="355-373" bases="AATAGGCGTATCACGAGGC"/></BindingSite><BindingSite simplified="1" location="355-373" boundStrand="0" annealedBases="AATAGGCGTATCACGAGGC" meltingTemperature="57"><Component hybridizedRange="355-373" bases="AATAGGCGTATCACGAGGC"/></BindingSite></Primer></Primers>
  ¸<Notes>
<UUID>6e135269-b15d-43d1-b2b5-15e00a12949e</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pCE35</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Description>C. auris LEUpOUT NAT marker CAS9 expression construct. Use with pCE27 gRNA expression construct..</Description>
<Created UTC="14:53:9">2021.12.8</Created>
<LastModified UTC="14:53:9">2021.12.8</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
<References>
<Reference title="Plasmids for markerless genome editing in C. auris" type="Journal Article" journal="Unpublished" journalName="Unpublished"/>
</References>
</Notes>
  Y     –         
?????                                                                                                       ÿ d      HO  d               E              ÿÿÿÿYô? P                                                                                                                                                              3<?xml version="1.0"?><EnzymeVisibilities vals=""/>
   )<?xml version="1.0"?><CustomEnzymeSets/>
